From Autostrada del Sole, A1 Milan-Rome, get off at the Florence Impruneta exit and follow the directions for downtown Florence. After about 1.5 km, there is a stop light by the tree-lined square near the Galluzzo home. Go straight to via Senese to Florence. After about 500 meters, at the large roundabout turn left and take the tunnel towards Scandicci. After the tunnel you will find another roundabout, take the second exit and immediately take on your right an uphill road, Via San Quirichino (you will see our signboard at the corner). After about 80 meters, you'll find in front of you the number 16 and the entrance to Marignolle Relais & Charme.
The Santa Maria Novella train station is only 6 kilometers (3,7 mi) from Relais Marignolle. You can easily reach the country estate by taxi or by booking the hotel's transfer service (for a fee).
The Florence Airport, Amerigo Vespucci, is 11 kilometers (7 mi) from Relais Marignolle and has an excellent 24 hour taxi service. Alternatively, you can book a transfer (fee-based) to the resort. There are many car rental companies at the airport such as Avis, Europcar, Maggiore, Hertz, etc.